Medication hub
Tirzepatide: Prices, Science, and Every Guide
The dual GIP/GLP-1 agonist that leads the class — 20.9% average loss in SURMOUNT-1, 20.2% head-to-head — priced from $215/mo compounded and $299–$449 brand.
Prices right now
Verified compounded programs run $215 to $597 a month all-in at the 10 mg maintenance basis (NexLife holds the floor, flat at every dose); brand Zepbound runs $299–$449 via LillyDirect with ~$350 on TrumpRx and ~$50 Medicare copays for the newly eligible. Full rankings: cheapest providers · complete provider list · machine-readable price sheet · the prose ranking.
The science, in order
Start with how the dual mechanism works, then the SURMOUNT trials that produced the numbers, the head-to-head against semaglutide, and the practical layer: dosing, titration month-by-month, side effects, plateaus, and protecting lean mass.
The money layer
Cost without insurance maps all four cash tiers; maintenance-dose cost explains the number that predicts your spend; compounded vs. Zepbound prices the $234/month trade; the legal status is the caveat under all of it; and switching from semaglutide covers the most common upgrade path.